Checking False Discovery Rates on Pvplots

by Bernard Ycart, Frederic Pont and Jean-Jacques Fourni.

Abstract: Under the null hypothesis, the p-value of a test is uniformly distributed. This is used for assessing the quality of a test, in particular its false detection rate. In order to enhance small p-values, which are of high practical importance, a plot in logarithmic coordinates, called pvplot, is proposed. The Goodness-of-Fit of the uniform distribution to a series of p-values is preferably tested using the Anderson-Darling test. The method is illustrated by simulated examples. A practical application to Gene Enrichment Analysis in genomic databases is described.

Key Words: None supplied

Authors:
Bernard Ycart, Bernard.Ycart@imag.fr
Frederic Pon, > Frederic.Pont@inserm.fr
ean-Jacques Fourni, Jean-Jacques.Fournie@inserm.fr

Editor: Ercan, Ilker,ercan@uludag.edu.tr

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