Size Procedures for Developmental Toxicity Studies

by Dale Bowman .

Abstract: Procedures for analyzing data from a developmental study in which litter size is treated as random are introduced. Most commonly used procedures for analyzing data of this type condition on litter size when modeling response rates. The effect of conditioning on litter size is examined and methods of estimating response rate in the presence of random litter size and intralitter correlation are developed and discussed.

Key Words: Correlated Binary Data; Dose-response; Litter Size.

Dale Bowman,

Editor: Xiao-hua Zhou

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